One-pot synthesis of high molar activity 6-[¹⁸F]fluoro-l-DOPA by Cu-mediated fluorination of a BPin precursor.

ABSTRACT: A one-pot two-step synthesis of 6-[¹⁸F]fluoro-l-DOPA ([¹⁸F]FDOPA) has been developed involving Cu-mediated radiofluorination of a pinacol boronate ester precursor. The method is fully automated, provides [¹⁸F]FDOPA in good activity yield (104 ± 16 mCi, 6 ± 1%), excellent radiochemical purity (>99%) and high molar activity (3799 ± 2087 Ci mmol^-1), n = 3, and has been validated to produce the radiotracer for human use.

SUBMITTER: Mossine AV 

PROVIDER: S-EPMC6812483 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature