Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial.

ABSTRACT:

Objective

To assess the efficacy of three months of antibiotic treatment compared with placebo in patients with chronic low back pain, previous disc herniation, and vertebral endplate changes (Modic changes).

Design

Double blind, parallel group, placebo controlled, multicentre trial.

Setting

Hospital outpatient clinics at six hospitals in Norway.

Participants

180 patients with chronic low back pain, previous disc herniation, and type 1 (n=118) or type 2 (n=62) Modic changes enrolled from June 2015 to September 2017.

Interventions

Patients were randomised to three months of oral treatment with either 750 mg amoxicillin or placebo three times daily. The allocation sequence was concealed by using a computer generated number on the prescription.

Main outc

SUBMITTER: Braten LCH 

PROVIDER: S-EPMC6812614 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature