A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB.

ABSTRACT: The non-canonical NF-κB signalling cascade is essential for lymphoid organogenesis, B cell maturation, osteoclast differentiation, and inflammation in mammals^1,2; dysfunction of this system is associated with human diseases, including immunological disorders and cancer^3-6. Although expression of NF-κB-inducing kinase (NIK, also known as MAP3K14) is the rate-limiting step in non-canonical NF-κB pathway activation^2,7, the mechanisms by which transcriptional responses are regulated remain largely unknown. Here we show that the sine oculis homeobox (SIX) homologue family transcription factors SIX1 and SIX2 are integral components of the non-canonical NF-κB signalling cascade. The developmentally silenced SIX proteins are reactivated in differentiated macrophage

SUBMITTER: Liu Z 

PROVIDER: S-EPMC6812682 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature