Development and validation of a patient-reported gout attack intensity score for use in gout clinical studies.

ABSTRACT:

Objective

Inflammation-related symptoms such as pain, swelling and tenderness of the affected joint are frequently assessed using 5-point diary rating scales in gout clinical trials. Combining these into a single gout attack symptom intensity score may be a useful summary measure for these data, which is potentially more responsive to change compared with the individual components. The objective of this study was to develop a patient-reported gout flare intensity score, the Gout Attack Intensity Score (GAIS), for use in clinical studies, that includes components for gout-related pain, swelling and tenderness.

Methods

Data from a randomized controlled trial comparing anakinra to standard of care for the treatment of acute gout attacks were used for this study. A 7-day flare d

SUBMITTER: Janssen CA 

PROVIDER: S-EPMC6812713 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature