Acute sprint exercise transcriptome in human skeletal muscle.

ABSTRACT:

Aim

To examine global gene expression response to profound metabolic and hormonal stress induced by acute sprint exercise.

Methods

Healthy men and women (n = 14) performed three all-out cycle sprints interspersed by 20 min recovery. Muscle biopsies were obtained before the first, and 2h and 20 min after last sprint. Microarray analysis was performed to analyse acute gene expression response and repeated blood samples were obtained.

Results

In skeletal muscle, a set of immediate early genes, FOS, NR4A3, MAFF, EGR1, JUNB were markedly upregulated after sprint exercise. Gene ontology analysis from 879 differentially expressed genes revealed predicted activation of various upstream regulators and downstream biofunctions. Gene signatures predicted an enhanced turnover of s

SUBMITTER: Rundqvist HC 

PROVIDER: S-EPMC6812755 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature