Effects of sonication parameters on transcranial focused ultrasound brain stimulation in an ovine model.

ABSTRACT: Low-intensity focused ultrasound (FUS) has significant potential as a non-invasive brain stimulation modality and novel technique for functional brain mapping, particularly with its advantage of greater spatial selectivity and depth penetration compared to existing non-invasive brain stimulation techniques. As previous studies, primarily carried out in small animals, have demonstrated that sonication parameters affect the stimulation efficiency, further investigation in large animals is necessary to translate this technique into clinical practice. In the present study, we examined the effects of sonication parameters on the transient modification of excitability of cortical and thalamic areas in an ovine model. Guided by anatomical and functional neuroimaging data specific to each animal,

SUBMITTER: Yoon K 

PROVIDER: S-EPMC6812789 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature