Phylogenetic correlations can suffice to infer protein partners from sequences.

ABSTRACT: Determining which proteins interact together is crucial to a systems-level understanding of the cell. Recently, algorithms based on Direct Coupling Analysis (DCA) pairwise maximum-entropy models have allowed to identify interaction partners among paralogous proteins from sequence data. This success of DCA at predicting protein-protein interactions could be mainly based on its known ability to identify pairs of residues that are in contact in the three-dimensional structure of protein complexes and that coevolve to remain physicochemically complementary. However, interacting proteins possess similar evolutionary histories. What is the role of purely phylogenetic correlations in the performance of DCA-based methods to infer interaction partners? To address this question, we employ controlled

SUBMITTER: Marmier G 

PROVIDER: S-EPMC6812855 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature