Early versus late initiation of renal replacement therapy for acute kidney injury in critically ill patients: A systematic review and meta-analysis.

ABSTRACT: BACKGROUND:Acute kidney injury is associated with high mortality, and is the most frequent complication encountered in patients residing in the intensive care unit. Although renal replacement therapy (RRT) is the standard of care for acute kidney injury, the optimal timing for initiation is still unknown. METHODS:We conducted a systemic review and meta-analysis of randomized controlled trials evaluating early versus late initiation of RRT in critically ill patients with acute kidney injury. We searched MEDLINE, Embase, and CENTRAL databases from inception to October 15, 2018. We screened studies and extracted data from published reported independently. The primary outcome was short-term mortality. RESULTS:A total of 2242 patients were included from 11 trials. No statistically significant e

SUBMITTER: Xiao L 

PROVIDER: S-EPMC6812871 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature