A qualitative transcriptional signature for predicting microsatellite instability status of right-sided Colon Cancer.

ABSTRACT:

Background

Microsatellite instability (MSI) accounts for about 15% of colorectal cancer and is associated with prognosis. Today, MSI is usually detected by polymerase chain reaction amplification of specific microsatellite markers. However, the instability is identified by comparing the length of microsatellite repeats in tumor and normal samples. In this work, we developed a qualitative transcriptional signature to individually predict MSI status for right-sided colon cancer (RCC) based on tumor samples.

Results

Using RCC samples, based on the relative expression orderings (REOs) of gene pairs, we extracted a signature consisting of 10 gene pairs (10-GPS) to predict MSI status for RCC through a feature selection process. A sample is predicted as MSI when the gene expression

SUBMITTER: Fu Y 

PROVIDER: S-EPMC6813057 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature