Functional characterization of canine wild type glucocorticoid receptor and an insertional mutation in a dog.

ABSTRACT: BACKGROUND:Glucocorticoids, among the most widely utilized drugs in veterinary medicine, are employed to treat a wide variety of diseases; however, their use often induces adverse events in dogs. The efficacy of glucocorticoids usually depends on dosage, although differences in sensitivity to glucocorticoids in individual animals have been reported. Glucocorticoids bind to the cytoplasmic glucocorticoid receptor (GR), which is expressed in almost all cells. These receptors are key factors in determining individual sensitivity to glucocorticoids. This study examined individual differences in glucocorticoid sensitivity in dogs, focusing on reactivity of the GR to prednisolone. RESULTS:We first molecularly cloned the GR gene from a healthy dog. We discovered a mutant GR in a dog suspected to

SUBMITTER: Yamanaka K 

PROVIDER: S-EPMC6813069 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature