A time-dependent genome-wide SNP-SNP interaction analysis of chicken body weight.

ABSTRACT:

Background

The important property of the quantitative traits of model organisms is time-dependent. However, the methodology for investigating the genetic interaction network over time is still lacking. Our study aims to provide insights into the mechanistic basis of epistatic interactions affecting the phenotypes of model organisms.

Results

We performed an exhaustive genome-wide search for significant SNP-SNP interactions associated with male birds' body weight (BW) (n = 475) at multiple time points (day of hatch (BW0) and 1, 3, 5, and 7 weeks (BW1, BW3, BW5, and BW7)). Statistical analysis detected 67, four, and two significant SNP pairs associated with BW0, BW1, and BW3, respectively, with a significance threshold at 8.67 × 10^- 12 (Bonferroni-adjusted: 1%). Mean

SUBMITTER: Li FG 

PROVIDER: S-EPMC6813082 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature