Vaccination or mass drug administration against schistosomiasis: a hypothetical cost-effectiveness modelling comparison.

ABSTRACT:

Background

Schistosomiasis is a neglected tropical disease, targeted by the World Health Organization for reduction in morbidity by 2020. It is caused by parasitic flukes that spread through contamination of local water sources. Traditional control focuses on mass drug administration, which kills the majority of adult worms, targeted at school-aged children. However, these drugs do not confer long-term protection and there are concerns over the emergence of drug resistance. The development of a vaccine against schistosomiasis opens the potential for control methods that could generate long-lasting population-level immunity if they are cost-effective.

Methods

Using an individual-based transmission model, matched to epidemiological data, we compared the cost-effectiveness of a

SUBMITTER: Collyer BS 

PROVIDER: S-EPMC6813092 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature