The prognostic impact of GSTM1/GSTP1 genetic variants in bladder Cancer.

ABSTRACT: BACKGROUND:The glutathione S-transferases (GSTs) are a superfamily of phase II detoxifying enzymes that inactivates a wide variety of potential carcinogens through glutathione conjugation. Polymorphic changes in the GST genes have been reported to be associated with increased susceptibility to cancer development and anticancer drug resistance. In this study, we investigated the association between genetic variants in GSTM1 and GSTP1 and patients' clinicopathological parameters. The prognostic values of such associations were evaluated among bladder cancer patients. METHODS:Genotyping of GSTM1 and GSTP1 in bladder cancer patients was assessed using polymerase chain reaction followed by DNA sequencing. Overall survival was estimated using the Kaplan-Meier method and multiple logistic regress

SUBMITTER: Albarakati N 

PROVIDER: S-EPMC6813104 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature