A novel rat model of tibial fracture for trauma researches: a combination of different types of fractures and soft tissue injuries.

ABSTRACT: BACKGROUND:The outcomes for open tibial fractures with severe soft tissue injury are still a great challenge for all the trauma surgeons in the treatment. However, most of the existing open tibial fracture models can only provide minimal soft tissue injury which cannot meet the requirement of severe trauma research. Our goal is to investigate a novel tibial fracture model providing different fractures combined with soft tissue injury for better application in trauma research. METHODS:A total of 144 Sprague-Dawley rats were randomly divided into 4 groups. With group 1 as control, the other groups sustained different right tibial fractures by the apparatus with buffer disc settings either 3 mm, 10 mm, or 15 mm. X-ray and computed tomography angiography (CTA) were performed at 6 h to evaluate

SUBMITTER: Shi E 

PROVIDER: S-EPMC6813134 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature