Performance evaluation of Cerenkov luminescence imaging: a comparison of 68Ga with 18F.

ABSTRACT: BACKGROUND:Cerenkov Luminescence Imaging (CLI) is an emerging technology for intraoperative margin assessment. Previous research only evaluated radionuclide 18-Fluorine (18F); however, for future applications in prostate cancer, 68-Gallium (68Ga) seems more suitable, given its higher positron energy. Theoretical calculations predict that 68Ga should offer a higher signal-to-noise ratio than 18F; this is the first experimental confirmation. The aim of this study is to investigate the technical performance of CLI by comparing 68Ga to 18F. RESULTS:The linearity of the system, detection limit, spatial resolution, and uniformity were determined with the LightPath imaging system. All experiments were conducted with clinically relevant activity levels in vitro, using dedicated phantoms. For both

SUBMITTER: Olde Heuvel J 

PROVIDER: S-EPMC6813407 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature