Compromised Bone Healing in Aged Rats Is Associated With Impaired M2 Macrophage Function.

ABSTRACT: Fracture repair is initiated by a multitude of immune cells and induction of an inflammatory cascade. Alterations in the early healing response due to an aged adaptive immune system leads to impaired bone repair, delayed healing or even formation of non-union. However, immuno-senescence is not limited to the adaptive immunity, but is also described for macrophages, main effector cells from the innate immune system. Beside regulation of pro- and anti-inflammatory signaling, macrophages contribute to angiogenesis and granulation tissue maturation. Thus, it seems likely that an altered macrophage function due to aging may affect bone repair at various stages and contribute to age related deficiencies in bone regeneration. To prove this hypothesis, we analyzed the expression of macrophage mark

SUBMITTER: Loffler J 

PROVIDER: S-EPMC6813416 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature