Expression of different ParE toxins results in conserved phenotypes with distinguishable classes of toxicity.

ABSTRACT: Toxin-antitoxin (TA) systems are found on both chromosomes and plasmids. These systems are unique in that they can confer both fatal and protective effects on bacterial cells-a quality that could potentially be harnessed given further understanding of these TA mechanisms. The current work focuses on the ParE subfamily, which is found throughout proteobacteria and has a sequence identity on average of approximately 12% (similarity at 30%-80%). Our aim is to evaluate the equivalency of chromosomally derived ParE toxin activity depending on its bacterial species of origin. Nine ParE toxins were analyzed, originating from six different bacterial species. Based on the resulting toxicity, three categories can be established: ParE toxins that do not exert toxicity under the experimental condition

SUBMITTER: Ames JR 

PROVIDER: S-EPMC6813445 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature