Asparagine Synthetase and Filamin A Have Different Roles in Ovarian Cancer.

ABSTRACT: Early-stage ovarian serous carcinoma is usually difficult to detect in clinical practice. The profiling of protein expression in high-grade serous carcinoma (HGSC) and low-grade serous carcinoma (LGSC) would provide important information for diagnoses and chemotherapy. Here, we performed proteomic profiling of specimens from 13 HGSC and 7 LGSC patients by iTRAQ. A total of 323 proteins that were differentially expressed were identified. After immunohistochemical confirmation of expressed proteins in 166 clinical tissues, asparagine synthetase (ASNS) and filamin A (FLNA) were selected for further functional study. Cisplatin-sensitive (CS; ASNS^high and FLNA^low) and cisplatin-resistant (CR; ASNS^low and FLNA^high) SKOV3 and OVCAR3 ovarian cancer cell

SUBMITTER: Zeng L 

PROVIDER: S-EPMC6813569 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature