External Replication of Urinary Bladder Cancer Prognostic Polymorphisms in the UK Biobank.

ABSTRACT: Introduction: Multiple studies have reported genetic associations with prognostic outcomes of urinary bladder cancer. However, the lack of replication of these associations prohibits establishing further evidence-based research directions. Moreover, there is a lack of independent bladder cancer patient samples that contain prognostic measures, making genetic replication analyses even more challenging. Materials and Methods: We have identified 1,534 eligible patients and used data on Hospital Episode Statistics in the UK Biobank to model variables of otherwise non-collected events on bladder cancer recurrence and progression. Data on survival was extracted from the Death Registry. We have used SNPTEST software to replicate previously reported genetic associations with bladder

SUBMITTER: Lipunova N 

PROVIDER: S-EPMC6813571 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature