Synaptic Proteome Alterations in the Primary Auditory Cortex of Individuals With Schizophrenia.

ABSTRACT:

Importance

Findings from unbiased genetic studies have consistently implicated synaptic protein networks in schizophrenia, but the molecular pathologic features within these networks and their contribution to the synaptic and circuit deficits thought to underlie disease symptoms remain unknown.

Objective

To determine whether protein levels are altered within synapses from the primary auditory cortex (A1) of individuals with schizophrenia and, if so, whether these differences are restricted to the synapse or occur throughout the gray matter.

Design, setting, and participants

This paired case-control study included tissue samples from individuals with schizophrenia obtained from the Allegheny County Office of the Medical Examiner. An independent panel of health care pro

SUBMITTER: MacDonald ML 

PROVIDER: S-EPMC6813579 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature