Association of Lipidomic Profiles With Progression of Carotid Artery Atherosclerosis in HIV Infection.

ABSTRACT:

Importance

Lipid metabolism disruption and excess risk of cardiovascular disease (CVD) have been observed in HIV-infected individuals, but the associations among HIV infection, plasma lipidome, and CVD risk have not been well understood.

Objective

To evaluate plasma lipidomic profiles and their associations with carotid artery atherosclerosis in individuals with HIV and individuals without HIV.

Design, setting, and participants

Prospective analysis in the Women's Interagency HIV Study and Multicenter AIDS Cohort Study during a 7-year follow-up (from 2004-2006 to 2011-2013) at multicenter HIV cohorts in the United States. The study included 737 participants aged 35 to 55 years (520 with HIV and 217 without HIV) without CVD or carotid artery plaque at baseline. Data wer

SUBMITTER: Chai JC 

PROVIDER: S-EPMC6813587 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature