Integrative Exome and Transcriptome Analysis of Conjunctival Melanoma and Its Potential Application for Personalized Therapy.

ABSTRACT:

Importance

Greater understanding of molecular features of conjunctival melanoma (CM) may improve its clinical management.

Objective

To evaluate molecular features of CM and application of this information into clinical care.

Design, setting, and participants

In a prospective case series of CM with integrative exome and transcriptome analysis, 8 patients at an academic ocular oncology setting were evaluated. The study was conducted from November 2015 to March 2018.

Interventions/exposures

Integrative exome and transcriptome analysis of CMs and clinical management of a patient's care by using this information.

Main outcomes and measures

Molecular characterization of CM and its potential clinical application.

Results

In the 8 patients (4 men) include

SUBMITTER: Demirci H 

PROVIDER: S-EPMC6813594 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature