Statins and gastroesophageal reflux disease: A meta-analysis.

ABSTRACT:

Background/objectives

Gastroesophageal reflux disease (GERD) is one of the common gastrointestinal disorders worldwide. Recent epidemiologic studies have suggested that use of statins may lower the risk of GERD although the results from different studies were inconsistent. This systematic review and meta-analysis were conducted with the aim to summarize all available data.

Methods

A systematic literature review was performed using MEDLINE and EMBASE database from inception to December 2017. Cohort, case-control, and cross-sectional studies that compared the risk of GERD among statin users versus nonusers were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method.

Results

A total of 4 st

SUBMITTER: Wijarnpreecha K 

PROVIDER: S-EPMC6813684 | biostudies-literature | 2019 Oct-Dec

REPOSITORIES: biostudies-literature