Assessment of acute bone loading in humans using [¹⁸F]NaF PET/MRI.

ABSTRACT:

Purpose

The acute effect of loading on bone tissue and physiology can offer important information with regard to joint function in diseases such as osteoarthritis. Imaging studies using [¹⁸F]-sodium fluoride ([¹⁸F]NaF) have found changes in tracer kinetics in animals after subjecting bones to strain, indicating an acute physiological response. The aim of this study is to measure acute changes in NaF uptake in human bone due to exercise-induced loading.

Methods

Twelve healthy subjects underwent two consecutive 50-min [¹⁸F]NaF PET/MRI examinations of the knees, one baseline followed by one post-exercise scan. Quantification of tracer kinetics was performed using an image-derived input function from the popliteal artery. For both scans, kinetic

SUBMITTER: Haddock B 

PROVIDER: S-EPMC6813760 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature