Apolipoprotein E Genotypes, Age, Race, and Cognitive Decline in a Population Sample.

ABSTRACT:

Objectives

To examine the effects of age and race on the association of apolipoprotein E (APOE) genotypes with cognitive decline in a population sample.

Design

Longitudinal study of 18 years' duration.

Setting

Biracial urban US population sample.

Participants

There were a total of 5807 participants, 60% African American (AA) and 40% European American (EA).

Measurements

A composite cognitive function based on individual tests of episodic memory, perceptual speed, and the Mini-Mental State Examination.

Results

The frequencies of APOE ε2/ε3 (14% vs 12%), ε2/ε4 (4% vs 2%), ε3/ε4 (29% vs 22%), and ε4/ε4 (4% vs 2%) genotypes were higher among AAs than EAs. After adjusting for demographic factors, the rate of decline in global cognition was twice as high

SUBMITTER: Rajan KB 

PROVIDER: S-EPMC6813761 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature