Restricted Hematopoietic Progenitors and Erythropoiesis Require SCF from Leptin Receptor+ Niche Cells in the Bone Marrow.

ABSTRACT: Hematopoietic stem cells (HSCs) are maintained in a perivascular niche in bone marrow, in which leptin receptor⁺ (LepR) stromal cells and endothelial cells synthesize factors required for HSC maintenance, including stem cell factor (SCF). An important question is why LepR⁺ cells are one hundred times more frequent than HSCs. Here, we show that SCF from LepR⁺ cells is also necessary to maintain many c-kit⁺-restricted hematopoietic progenitors. Conditional deletion of Scf from LepR⁺ cells depleted common myeloid progenitors (CMPs), common lymphoid progenitors (CLPs), granulocyte-macrophage progenitors (GMPs), megakaryocyte-erythrocyte progenitors (MEPs), pre-megakaryocyte-erythrocyte progenitors (PreMegEs), and colony-forming units-eryth

SUBMITTER: Comazzetto S 

PROVIDER: S-EPMC6813769 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature