The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis.

ABSTRACT: Two types of monocytes, Ly6C^hi and Ly6C^lo, infiltrate the heart in murine experimental autoimmune myocarditis (EAM). We discovered a role for cardiac fibroblasts in facilitating monocyte-to-macrophage differentiation of both Ly6C^hi and Ly6C^lo cells, allowing these macrophages to perform divergent functions in myocarditis progression. During the acute phase of EAM, IL-17A is highly abundant. It signals through cardiac fibroblasts to attenuate efferocytosis of Ly6C^hi monocyte-derived macrophages (MDMs) and simultaneously prevents Ly6C^lo monocyte-to-macrophage differentiation. We demonstrated an inverse clinical correlation between heart IL-17A levels and efferocytic receptor expressions in humans with heart failure (HF). In th

SUBMITTER: Hou X 

PROVIDER: S-EPMC6813836 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature