Systemic inflammation is associated with depressive symptoms differentially by sex and race: a longitudinal study of urban adults.

ABSTRACT: Systemic inflammation may influence trajectories of depressive symptoms over time, perhaps differentially by sex and race. Inflammatory markers and the Center for Epidemiologic Studies-Depression scale [total score: CES-D_total and four distinctive domains: somatic complaints, depressed affect, positive affect and interpersonal problems] were examined among African-American (AA) and White urban adults participating in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study [2004-2013, Age_base:30-64 y, mean ± SD follow-up time: 4.64 ± 0.93 y, N = 150 (with cytokine data) to N = 1,767 (with other inflammatory markers)]. Findings suggest that serum concentrations of high-sensitivity C-reactive protein (hsCRP), z-inflammation composite score [IC

SUBMITTER: Beydoun MA 

PROVIDER: S-EPMC6813878 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature