Acid-Sensing Ion Channels: Novel Mediators of Cerebral Vascular Responses.

ABSTRACT:

Rationale

Precise regulation of cerebral blood flow is critical for normal brain function. Insufficient cerebral blood flow contributes to brain dysfunction and neurodegeneration. Carbon dioxide (CO₂), via effects on local acidosis, is one of the most potent regulators of cerebral blood flow. Although a role for nitric oxide in intermediate signaling has been implicated, mechanisms that initiate CO₂-induced vasodilation remain unclear.

Objective

Acid-sensing ion channel-1A (ASIC1A) is a proton-gated cation channel that is activated by extracellular acidosis. Based on work that implicated ASIC1A in the amygdala and bed nucleus of the stria terminalis in CO₂-evoked and acid-evoked behaviors, we hypothesized that ASIC1A might also mediate microv

SUBMITTER: Faraci FM 

PROVIDER: S-EPMC6813889 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature