Fibroblast as a critical stromal cell type determining prognosis in prostate cancer.

ABSTRACT:

Background

Tumor stroma associates with prostate cancer (PCa) progression, but its specific cellular composition and association to patient survival outcome have not been characterized.

Methods

We analyzed stromal composition in human PCa using multiplex immunohistochemistry and quantitative, high-resolution image analysis in two retrospective, formalin-fixed paraffin embedded observational clinical cohorts (Cohort I, n = 117; Cohort II, n = 340) using PCa-specific mortality as outcome measurement.

Results

A high proportion of fibroblasts associated with aggressive disease and castration-resistant prostate cancer (CRPC). In a multivariate analysis, increase in fibroblast proportion predicted poor cancer-specific outcome independently in the two clinical cohorts studie

SUBMITTER: Blom S 

PROVIDER: S-EPMC6813917 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature