Choline Kinase Emerges as a Promising Drug Target in Gram-Positive Bacteria.

ABSTRACT: Both nosocomial pathogens, such as Streptococcus pneumoniae and Haemophilus influenzae and food-borne pathogens, such as Bacillus cereus and Clostridium perfringens are known to be detrimental to human and animal health. The effectiveness of currently used treatments for these pathogens becomes limited as resistant strains emerge. Therefore, new methods for eliminating bacterial pathogens must be developed continuously. This includes establishing novel targets to which drug discovery efforts could be focused. A promising method for discovering new drug targets in prokaryotes is to take advantage of the information available regarding the enzymatic pathways that have been established as drug targets in eukaryotic systems and explore the analogous pathways found in bacterial systems. This is

SUBMITTER: Zimmerman T 

PROVIDER: S-EPMC6813931 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature