Biomarkers associating endothelial Dysregulation in pediatric-onset systemic lupus erythematous.

ABSTRACT: BACKGROUND/PURPOSE:Endothelium is a key element in the regulation of vascular homeostasis and its alteration can lead to the development of vascular diseases. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with potential extensive vascular lesions, involving skin vessels, renal glomeruli, cardiovascular system, brain, lung alveoli, gastrointestinal tract vessels and more. We aimed to assess endothelial dysregulation related biomarkers in pediatric-onset SLE (pSLE) patient serum and elucidate its correlation with their clinical features, laboratory parameters, and the overall disease activity. METHODS:Disease activities were evaluated by SLE disease activity index (SLEDAI). Patient characteristics were obtained by retrospective chart review. Six biomarkers associated wi

SUBMITTER: Lee WF 

PROVIDER: S-EPMC6814049 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature