Oral antibiotics for neonatal infections: a systematic review and meta-analysis.

ABSTRACT:

Background

Worldwide many neonates suffer from bacterial infections. Adequate treatment is important but is associated with prolonged hospitalization for intravenous administration. In older children, oral switch therapy has been proven effective and safe for several indications and is now standard care.

Objectives

To evaluate the currently available evidence on pharmacokinetics, safety and efficacy of oral antibiotics and oral switch therapy in neonates (0-28 days old).

Methods

We performed systematic searches in Medline, Embase.com, Cochrane, Google Scholar and Web of Science. Studies were eligible if they described the use of oral antibiotics in neonates (0-28 days old), including antibiotic switch studies and pharmacological studies.

Results

Thirty-one stud

SUBMITTER: Keij FM 

PROVIDER: S-EPMC6814091 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature