Low-level cyclic tibial compression attenuates early osteoarthritis progression after joint injury in mice.

ABSTRACT: OBJECTIVE:Mechanical loading and joint health have a unique relationship in osteoarthritis (OA) onset and progression. Although high load levels adversely affect cartilage health, exercise that involves low to moderate load levels can alleviate OA symptoms. We sought to isolate the beneficial effects of mechanical loading using controlled in vivo cyclic tibial compression. We hypothesized that low-level cyclic compression would attenuate post-traumatic OA symptoms induced by destabilization of the medial meniscus (DMM). METHODS:10-week-old C57Bl/6J male mice underwent DMM surgery (n = 51). After a 5-day post-operative recovery period, we applied daily cyclic tibial compression to the operated limbs at low (1.0N or 2.0N) or moderate (4.5N) magnitudes for 2 or 6 weeks. At the completion of l

SUBMITTER: Holyoak DT 

PROVIDER: S-EPMC6814162 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature