Monitoring and characterizing soluble and membrane-bound ectonucleotidases CD73 and CD39.

ABSTRACT: The success of immunotherapy treatment in oncology ushered a new modality for treating a wide variety of cancers. However, lack of effect in some patients made it imperative to identify other pathways that are exploited by cancer cells to circumvent immune surveillance, and possibly synergize immune checkpoint treatment in those cases. It has been recently recognized that adenosine levels increase significantly in the tumor microenvironment and that adenosine/adenosine receptors play a powerful role as immunosuppressive and attenuating several effector T cell functions. The two main enzymes responsible for generating adenosine in the microenvironment are the ectonucleotidases CD39 and CD73, the former utilizes both ATP and ADP and produces AMP while the latter utilizes AMP and generates ad

SUBMITTER: Goueli SA 

PROVIDER: S-EPMC6814236 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature