Subcortical heterotopic gray matter brain malformations: Classification study of 107 individuals.

ABSTRACT:

Objective

To better evaluate the imaging spectrum of subcortical heterotopic gray matter brain malformations (subcortical heterotopia [SUBH]), we systematically reviewed neuroimaging and clinical data of 107 affected individuals.

Methods

SUBH is defined as heterotopic gray matter, located within the white matter between the cortex and lateral ventricles. Four large brain malformation databases were searched for individuals with these malformations; data on imaging, clinical outcomes, and results of molecular testing were systematically reviewed and integrated with all previously published subtypes to create a single classification system.

Results

Review of the databases revealed 107 patients with SUBH, the large majority scanned during childhood (84%), including more

SUBMITTER: Oegema R 

PROVIDER: S-EPMC6814414 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature