Pleiotropy informed adaptive association test of multiple traits using genome-wide association study summary data.

ABSTRACT: Genetic variants associated with disease outcomes can be used to develop personalized treatment. To reach this precision medicine goal, hundreds of large-scale genome-wide association studies (GWAS) have been conducted in the past decade to search for promising genetic variants associated with various traits. They have successfully identified tens of thousands of disease-related variants. However, in total these identified variants explain only part of the variation for most complex traits. There remain many genetic variants with small effect sizes to be discovered, which calls for the development of (a) GWAS with more samples and more comprehensively genotyped variants, for example, the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program is planning to conduct whole genome sequencin

SUBMITTER: Masotti M 

PROVIDER: S-EPMC6814451 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature