Depression Severity Over 27 Months in Adolescent Girls Is Predicted by Stress-Linked Cortical Morphology.

ABSTRACT:

Background

Evidence supports the notion that early-life stress and trauma impact cortical development and increase vulnerability to depression. However, it remains unclear whether common stressful life events in community-dwelling adolescents have similar consequences for cortical development.

Methods

A total of 232 adolescent girls (mean age 15.29 ± 0.65 years) were assessed with the Stressful Life Events Schedule (a semistructured interview of stressors in the previous 9 months) and underwent a magnetic resonance imaging scan. FreeSurfer 5.3.0 was used to perform whole-brain surface-based morphometry. Dysphoria was assessed at the time of imaging and prospectively at three 9-month follow-up appointments using the Inventory of Depression and Anxiety Symptoms II.

Results<

SUBMITTER: Bartlett EA 

PROVIDER: S-EPMC6814528 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature