Dynamic interactions between the extracellular matrix and estrogen activity in progression of ER+ breast cancer.

ABSTRACT: Metastatic, antiestrogen resistant estrogen receptor α positive (ER+) breast cancer is the leading cause of breast cancer deaths in USA women. While studies have demonstrated the importance of the stromal tumor microenvironment in cancer progression and therapeutic responses, effects on the responses of ER+ cancers to estrogen and antiestrogens are poorly understood, particularly in the complex in vivo environment. In this study, we used an estrogen responsive syngeneic mouse model to interrogate how a COL1A1-enriched fibrotic ECM modulates integrated hormonal responses in cancer progression. We orthotopically transplanted the ER+ TC11 cell line into wild-type (WT) or collagen-dense (Col1a1^tm1Jae/+, mCol1a1) syngeneic FVB/N female mice. Once tumors were established, recipients w

SUBMITTER: Jallow F 

PROVIDER: S-EPMC6814534 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature