Triple-gated motion and blood pool clearance corrections improve reproducibility of coronary ¹⁸F-NaF PET.

ABSTRACT:

Purpose

To improve the test-retest reproducibility of coronary plaque ¹⁸F-sodium fluoride (¹⁸F-NaF) positron emission tomography (PET) uptake measurements.

Methods

We recruited 20 patients with coronary artery disease who underwent repeated hybrid PET/CT angiography (CTA) imaging within 3 weeks. All patients had 30-min PET acquisition and CTA during a single imaging session. Five PET image-sets with progressive motion correction were reconstructed: (i) a static dataset (no-MC), (ii) end-diastolic PET (standard), (iii) cardiac motion corrected (MC), (iv) combined cardiac and gross patient motion corrected (2 × MC) and, (v) cardiorespiratory and gross patient motion corrected (3 × MC). In addition to motion correction, all datasets were corrected for vari

SUBMITTER: Lassen ML 

PROVIDER: S-EPMC6814554 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature