Phenotypes of Chronic Hepatitis B in Children From a Large North American Cohort.

ABSTRACT:

Objective

The aim of the study was to define chronic HBV phenotypes in a large, cohort of United States and Canadian children utilizing recently published population-based upper limit of normal alanine aminotransferase levels (ULN ALT), compared with local laboratory ULN; identify relationships with host and viral factors.

Background

Chronic hepatitis B virus (HBV) infection has been characterized by phases or phenotypes, possibly associated with prognosis and indications for therapy.

Methods

Baseline enrollment data of children in the Hepatitis B Research Network were examined. Phenotype definitions were inactive carrier: HBeAg-negative with low HBV DNA and normal ALT levels; immune-tolerant: HBeAg-positive with high HBV DNA but normal ALT levels; or chronic hepatiti

SUBMITTER: Schwarz KB 

PROVIDER: S-EPMC6814562 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature