Systematic profiling of alternative splicing events and splicing factors in left- and right-sided colon cancer.

ABSTRACT: Left- and right-sided colon cancer (LC and RC) differ substantially in their molecular characteristics and prognoses, and are thus treated using different strategies. We systematically analyzed alternative splicing (AS) events and splicing factors in LC and RC. RNA-seq data were used for genome-wide profiling of AS events that could distinguish LC from RC. The Exon Skip splicing pattern was more common in RC, while the Retained Intron pattern was more common in LC. The AS events that were upregulated in RC were enriched for genes in the axon guidance pathway, while those that were upregulated in LC were enriched for genes in immune-related pathways. Prognostic models based on differentially expressed AS events were built, and a prognostic signature based on these AS events performed well f

SUBMITTER: Huang X 

PROVIDER: S-EPMC6814588 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature