Conserved aging-related signatures of senescence and inflammation in different tissues and species.

ABSTRACT: Increasing evidence indicates that chronic inflammation and senescence are the cause of many severe age-related diseases, with both biological processes highly upregulated during aging. However, until now, it has remained unknown whether specific inflammation- or senescence-related genes exist that are common between different species or tissues. These potential markers of aging could help to identify possible targets for therapeutic interventions of aging-associated afflictions and might also deepen our understanding of the principal mechanisms of aging. With the objective of identifying such signatures of aging and tissue-specific aging markers, we analyzed a multitude of cross-sectional RNA-Seq data from four evolutionarily distinct species (human, mouse and two fish) and four different

SUBMITTER: Barth E 

PROVIDER: S-EPMC6814591 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature