Spring peaks and autumn troughs identified in peripheral inflammatory markers during the peripartum period.

ABSTRACT: Seasonal variations have recently been described in biomarkers, cell types, and gene expression associated with the immune system, but so far no studies have been conducted among women in the peripartum period. It is of note that pregnancy complications and outcomes, as well as autoimmune diseases, have also been reported to exhibit seasonal fluctuations. We report here a clear-cut seasonal pattern of 23 inflammatory markers, analysed using proximity-extension assay technology, in pregnant women. The inflammatory markers generally peaked in the spring and had a trough in the autumn. During the postpartum period we found seasonality in one inflammatory marker, namely monocyte chemotactic protein 4 (MCP-4). Our findings suggest that seasonal variations in peripheral inflammatory markers are

SUBMITTER: Henriksson HE 

PROVIDER: S-EPMC6814733 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature