[HIV-2 infection in Senegal: virological failures and resistance to antiretroviral drugs (ARVs)].

ABSTRACT:

Introduction

HIV-2, endemic in West Africa, has a natural resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) which makes it difficult to treat it in developing countries.

Methods

We conducted a descriptive, longitudinal, prospective study over the period November 2005-June 2017. Virologic failure has been defined as any viral load greater than 50 copies/ml after 6 months of ARV treatment administered twice. Assays for detecting drug-resistance mutations was performed in the protease-coding region and in the reverse transcriptase-coding region.

Results

Data from a total of 110 patients were collected. The patients had a median age of 46 years (ranging from 18 to 67) with a sex-ratio F/M of 2.54. At inclusion, viral load could be assessed in 44% of c

SUBMITTER: Ba S 

PROVIDER: S-EPMC6814923 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature