Activated spinal astrocytes contribute to the later phase of carrageenan-induced prostatitis pain.

ABSTRACT: BACKGROUND:Prostatodynia is the main symptom of chronic prostatitis and the main reason that patients go to the hospital for treatment. Although a variety of factors, including inflammatory immune response, nervous system sensitization, and psychological factors, have been shown to play important roles in the induction and development of chronic pain in prostatitis, the underlying cause of chronic prostatodynia maintenance in prostatitis patients remains unclear. METHODS:A mouse model of chronic prostatitis induced by carrageenan injection was used. The von Frey test was used to measure pain behavior. The microglial and astrocyte activations were immunohistochemically demonstrated with antibodies against Iba1 and GFAP. The expression of cytokine or signaling pathway was detected by enzyme-

SUBMITTER: Deng GC 

PROVIDER: S-EPMC6814979 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature