The impact of D-cycloserine and sarcosine on in vivo frontal neural activity in a schizophrenia-like model.

ABSTRACT: BACKGROUND:N-methyl-D-aspartate receptor (NMDAR) hypofunction has been proposed to underlie the pathogenesis of schizophrenia. Specifically, reduced function of NMDARs leads to altered balance between excitation and inhibition which further drives neural network malfunctions. Clinical studies suggested that NMDAR modulators (glycine, D-serine, D-cycloserine and glycine transporter inhibitors) may be beneficial in treating schizophrenia patients. Preclinical evidence also suggested that these NMDAR modulators may enhance synaptic NMDAR function and synaptic plasticity in brain slices. However, an important issue that has not been addressed is whether these NMDAR modulators modulate neural activity/spiking in vivo. METHODS:By using in vivo calcium imaging and single unit recording, we tested

SUBMITTER: Yao L 

PROVIDER: S-EPMC6814999 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature