Dissecting the genetic basis of comorbid epilepsy phenotypes in neurodevelopmental disorders.

ABSTRACT: BACKGROUND:Neurodevelopmental disorders (NDDs) such as autism spectrum disorder, intellectual disability, developmental disability, and epilepsy are characterized by abnormal brain development that may affect cognition, learning, behavior, and motor skills. High co-occurrence (comorbidity) of NDDs indicates a shared, underlying biological mechanism. The genetic heterogeneity and overlap observed in NDDs make it difficult to identify the genetic causes of specific clinical symptoms, such as seizures. METHODS:We present a computational method, MAGI-S, to discover modules or groups of highly connected genes that together potentially perform a similar biological function. MAGI-S integrates protein-protein interaction and co-expression networks to form modules centered around the selection of a

SUBMITTER: Chow J 

PROVIDER: S-EPMC6815046 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature