Fast-diffusing p75^NTR monomers support apoptosis and growth cone collapse by neurotrophin ligands.

ABSTRACT: The p75 neurotrophin (NT) receptor (p75^NTR) plays a crucial role in balancing survival-versus-death decisions in the nervous system. Yet, despite 2 decades of structural and biochemical studies, a comprehensive, accepted model for p75^NTR activation by NT ligands is still missing. Here, we present a single-molecule study of membrane p75^NTR in living cells, demonstrating that the vast majority of receptors are monomers before and after NT activation. Interestingly, the stoichiometry and diffusion properties of the wild-type (wt) p75^NTR are almost identical to those of a receptor mutant lacking residues previously believed to induce oligomerization. The wt p75^NTR and mutated (mut) p75^NTR differ in their partitioning in choleste

SUBMITTER: Marchetti L 

PROVIDER: S-EPMC6815156 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature