L-type voltage-gated Ca²⁺ channel Ca_V1.2 regulates chondrogenesis during limb development.

ABSTRACT: All cells, including nonexcitable cells, maintain a discrete transmembrane potential (V _mem), and have the capacity to modulate V _mem and respond to their own and neighbors' changes in V _mem Spatiotemporal variations have been described in developing embryonic tissues and in some cases have been implicated in influencing developmental processes. Yet, how such changes in V _mem are converted into intracellular inputs that in turn regulate developmental gene expression and coordinate patterned tissue formation, has remained elusive. Here we document that the V _mem of limb mesenchyme switches from a hyperpolarized to depolarized state during early chondrocyte differentiation. This change in V

SUBMITTER: Atsuta Y 

PROVIDER: S-EPMC6815189 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature